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The zebrafish organizer

A F Schier¹, W S Talbot

¹Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA. schier@saturn.med.nyu.edu

Current Opinion in Genetics & Development

|September 8, 1998

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Zebrafish organizer signals, including BMP2 and chordin, pattern embryos. A novel EGF-like gene, one-eyed pinhead, is crucial for prechordal plate and endoderm development and nervous system patterning.

Area of Science:

Developmental biology
Embryogenesis
Molecular genetics

Background:

The organizer is critical for vertebrate embryonic patterning.
Previous research highlighted BMP2 and chordin in organizer function.

Purpose of the Study:

To investigate the role of novel genes in zebrafish organizer function.
To understand the molecular mechanisms of prechordal plate and endoderm formation.
To identify factors involved in nervous system anterior-posterior axis patterning.

Main Methods:

Molecular analysis of zebrafish mutations.
Embryological studies.
Identification of novel genes, including EGF-like genes.

Main Results:

Related Experiment Videos

Established essential roles for BMP2 and chordin in organizer function.
Identified one-eyed pinhead as a novel EGF-like gene involved in prechordal plate and endoderm formation.
Defined two novel organizing centers that pattern the nervous system.

Conclusions:

Organizer signals are crucial for vertebrate embryonic patterning.
BMP2, chordin, and the novel gene one-eyed pinhead are key molecular players.
Extraembryonic cues and novel organizing centers pattern the nervous system.