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Microcircuitry and function of the inferior olive

C I De Zeeuw1, J I Simpson, C C Hoogenraad

  • 1Dept of Anatomy, Erasmus University Rotterdam, The Netherlands.

Trends in Neurosciences
|September 15, 1998
PubMed
Summary

The inferior olive

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Area of Science:

  • Neuroscience
  • Cerebellar Function
  • Motor Control

Background:

  • The inferior olive projects climbing fibers to cerebellar Purkinje cells.
  • Its role in motor learning, timing, and movement comparison is debated.
  • Olivocerebellar circuitry involves unique glomeruli with combined inputs.

Purpose of the Study:

  • To review the function of the inferior olive based on its microcircuitry.
  • To propose a model for olivocerebellar function.
  • To clarify the role of the inferior olive in motor control.

Main Methods:

  • Review of existing literature on inferior olive structure and function.
  • Analysis of the microcircuitry of the olivary neuropil, including glomeruli.
  • Comparison with computational models (Segev and Rall) of neuronal function.

Main Results:

  • The inferior olive's microcircuitry, with its glomeruli, supports combined excitatory and inhibitory inputs.
  • Dendritic spines are coupled by gap junctions, suggesting network interactions.
  • A computational model suggests applicability to olivary spine morphology and input.

Conclusions:

  • The microcircuitry of the inferior olive is capable of motor learning and motor timing.
  • The inferior olive does not directly compare intended with achieved movements.
  • Olivocerebellar function is best understood through its unique microcircuit architecture.

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