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Related Experiment Videos

Encapsulation of proteins for improved delivery

S D Putney1

  • 1Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. sputney@lilly.com

Current Opinion in Chemical Biology
|September 16, 1998
PubMed
Summary
This summary is machine-generated.

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Injectable sustained-release protein formulations are now possible thanks to cryogenic atomization and improved protein stability methods. These advances allow less frequent dosing and may enable new protein drug development.

Area of Science:

  • Biotechnology
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • Clinically useful injectable, sustained-release protein formulations were previously limited.
  • Protein drugs often require frequent administration, impacting patient compliance and cost.
  • Stability of proteins within delivery systems is a significant challenge.

Purpose of the Study:

  • To describe recent advances enabling injectable, sustained-release protein formulations.
  • To highlight the potential benefits of these new formulations for protein drug delivery.
  • To explore the commercial viability of previously undeveloped protein therapeutics.

Main Methods:

  • Development of a nonaqueous, cryogenic atomization process for protein encapsulation.
  • Creation of biodegradable polymer microspheres for controlled protein release.

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  • Implementation of strategies to ensure protein stability within microspheres post-injection.

    • Main Results:

    • Successful encapsulation of proteins into biodegradable microspheres.
    • Demonstrated slow release of proteins from microspheres after injection.
    • Achieved enhanced protein stability within the microspheres for extended durations.

    Conclusions:

    • Two key advances facilitate clinically useful, injectable, sustained-release protein formulations.
    • These formulations allow for less frequent administration and potentially lower doses.
    • Sustained-release technology may enable the commercialization of novel protein therapeutics.