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Thyroid scintigraphy in children with hypothyroidism: a five-year experience
P Pusuwan1, S Likitmaskul, S Wacharasindhu
1Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|September 16, 1998
Summary
Thyroid scintigraphy is crucial for diagnosing cretinism in children. This imaging technique helps identify thyroid gland presence, absence, or abnormal location, aiding genetic and prognostic counseling.
Area of Science:
- Pediatric Endocrinology
- Nuclear Medicine
- Medical Imaging
Background:
- Thyroid scintigraphy is vital for diagnosing cretinism.
- Accurate diagnosis impacts genetic counseling and sibling screening.
- Understanding thyroid tissue presence is key for patient management.
Purpose of the Study:
- To evaluate the utility of technetium-99m-pertechnetate thyroid scintigraphy in children with cretinism.
- To categorize thyroid gland localization based on scintigraphic findings.
- To assess the role of the perchlorate discharge test in identifying organification defects.
Main Methods:
- Technetium-99m-pertechnetate thyroid scintigraphy performed on 27 children with cretinism.
- Classification of thyroid localization into athyrotic, ectopic, or normal position.
- Perchlorate discharge test conducted on a subset of patients with normally positioned glands.
Main Results:
- 48.1% of children were athyrotic (lacked thyroid tissue).
- 11.1% had an ectopic thyroid (abnormally located).
- 40.8% had a normally positioned thyroid gland, with 8 positive perchlorate discharge tests indicating organification defects.
Conclusions:
- Thyroid scintigraphy effectively determines thyroid tissue presence and location in pediatric cretinism.
- The perchlorate discharge test aids in diagnosing organification defects.
- These diagnostic tools are valuable for diagnosis, follow-up, and prognosis in children with cretinism.