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Multiple primary melanomas

T M Johnson1, T Hamilton, L Lowe

  • 1University of Michigan Medical Center and Comprehensive Cancer Center, Ann Arbor, USA.

Journal of the American Academy of Dermatology
|September 17, 1998
PubMed
Summary
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Patients diagnosed with melanoma have an increased risk of developing subsequent primary melanomas, often in different locations years later. Early detection of multiple melanomas is crucial.

Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Primary melanoma diagnosis is a significant risk factor for developing additional primary melanomas.
  • Understanding the characteristics of patients with multiple melanomas is essential for risk stratification and management.

Purpose of the Study:

  • To characterize the subgroup of patients diagnosed with multiple primary melanomas.
  • To identify patterns in the occurrence, location, and timing of subsequent melanomas.

Main Methods:

  • Retrospective review of a melanoma database.
  • Identification and analysis of patients with multiple primary melanomas.

Main Results:

  • Sixty patients with multiple primary melanomas were identified.

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  • Subsequent melanomas frequently occurred in different locations (72%) and often years after the initial diagnosis (42% after >7 years).
  • Subsequent melanomas were thinner in 70% of cases, and patients with dysplastic nevi were diagnosed younger.

    • Conclusions:

    • Multiple primary melanomas represent a distinct clinical entity.
    • Subsequent melanomas commonly arise in different body regions and years post-initial diagnosis.
    • Factors such as dysplastic nevi influence the age of initial melanoma diagnosis.