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[Ketoprofen-induced contact photosensitivity disorders: 5 cases]
M Bastien1, B Milpied-Homsi, S Baudot
1Clinique Dermatologique, CHU Nantes.
Annales De Dermatologie Et De Venereologie
|January 1, 1997
Summary
Topical nonsteroidal anti-inflammatory drugs (NSAID) like ketoprofen can cause skin reactions. This study confirms ketoprofen
Area of Science:
- Dermatology
- Pharmacology
- Photobiology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAID) are frequently used topically for benign conditions.
- Adverse skin reactions, including contact eczema and photocontact dermatitis, are known NSAID side effects.
- Arylpropionic acid derivatives, such as ketoprofen, are often implicated in these reactions.
Observation:
- Five patients developed eczema after applying ketoprofen gel (Ketum) to sun-exposed skin.
- Photoallergy testing revealed positive photopatch-tests for ketoprofen under UVA and broad-spectrum light.
- Histological examination of a positive photopatch-test biopsy supported a photoallergic mechanism.
Findings:
- Ketoprofen exhibits photosensitizing potential within the UVA spectrum.
- The observed cases suggest a photoallergic reaction to topical ketoprofen.
- Control tests in healthy individuals yielded negative results, strengthening the link to ketoprofen.
Implications:
- Physicians should be aware of ketoprofen's photosensitivity potential.
- Healthcare providers should consider photoallergic reactions when diagnosing skin issues after topical NSAID use.
- Reporting adverse reactions to pharmacovigilance centers is crucial for monitoring drug safety.