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[Choroid infiltration in myelodysplastic syndrome]
F Madjlessi1, K Dann, C Althaus
1Augenklinik der Heinrich-Heine-Universität Düsseldorf.
Klinische Monatsblatter Fur Augenheilkunde
|September 23, 1998
Summary
This case report highlights choroidal infiltration as an early indicator of myelodysplastic syndrome progressing to acute myeloid leukemia. Prompt diagnosis and treatment significantly improved vision and patient outcomes.
Area of Science:
- Hematology
- Ophthalmology
- Oncology
Background:
- Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder.
- Progression to acute myeloid leukemia (AML) is a known complication of MDS.
- Ocular involvement is common in advanced leukemia but rare in MDS progression.
Observation:
- A 70-year-old male with MDS presented with sudden, severe vision loss in one eye.
- Ophthalmologic examination revealed choroidal infiltration, diagnosed via clinical findings, ultrasound, and angiography.
- Hematologic remission of MDS was noted prior to ocular symptoms.
Findings:
- Ophthalmologic findings prompted bone marrow aspiration, revealing progression of MDS to AML.
- The patient received prompt chemotherapy and radiation therapy to the affected eye.
- Complete resolution of choroidal lesions and visual recovery to 0.8 were achieved within 10 days.
Implications:
- This case suggests choroidal infiltration can be an initial sign of MDS transforming into AML.
- Early diagnosis of this transformation through ophthalmologic findings is critical.
- Timely therapeutic intervention is crucial for improving prognosis and prolonging survival in MDS patients.