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[Radiosurgery of brain metastasis]
X Muracciole1, J Régis, J C Peragut
1Département de neuroradiochirurgie stéréotaxique-Leksell gamma-unit, CHU La Timone, Marseille, France.
Summary
Stereotactic radiosurgery offers an effective, non-invasive treatment for brain metastases, achieving an 86% local control rate with low morbidity. This technique is particularly beneficial for tumors resistant to conventional radiation.
Area of Science:
- Neurosurgery
- Radiation Oncology
Context:
- Brain metastases pose a significant challenge in cancer care.
- Conventional therapies have limitations in efficacy and morbidity.
- Radiosurgery has emerged as a promising alternative treatment modality.
Purpose:
- To evaluate the efficacy and safety of radiosurgery for treating brain metastases.
- To compare radiosurgery outcomes with conventional treatment approaches.
- To identify prognostic factors influencing survival and local control.
Summary:
- Radiosurgery delivers a precise, high-dose radiation fraction to intracranial tumors, minimizing damage to surrounding healthy brain tissue.
- It demonstrates high local control rates (86%) and is effective for radioresistant tumors like those from melanoma and renal carcinoma.
- Morbidity is low, with symptomatic edema in 5-10% of cases and radiation necrosis in <5%.
Impact:
- Radiosurgery provides a valuable, minimally invasive option for surgically inaccessible or recurrent brain tumors.
- It offers an alternative to surgery and whole-brain irradiation, improving patient outcomes.
- Ongoing studies aim to further define its role by evaluating local control and survival rates without neurological symptoms.