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Bilateral non-familial renal cell carcinoma
G Grimaldi1, V Reuter, P Russo
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Annals of Surgical Oncology
|October 1, 1998
Summary
Non-familial bilateral renal cell carcinoma (RCC) in sporadic forms shows a good prognosis. Partial nephrectomy is key, and long-term follow-up is essential for synchronous and asynchronous tumors.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- Bilateral renal cell carcinoma (RCC) can be hereditary or sporadic.
- This study focuses on the clinical description of non-hereditary, apparently sporadic bilateral RCC.
Purpose of the Study:
- To describe the clinical characteristics of non-familial bilateral renal cell carcinoma.
- To evaluate the outcomes and survival rates for this patient subgroup.
Main Methods:
- Retrospective analysis of 698 patients with RCC between 1989-1997.
- Identified 33 patients with bilateral RCC, focusing on 29 non-familial cases.
- Utilized Kaplan-Meier for survival analysis and Mann-Whitney test for comparisons.
Main Results:
- Non-familial bilateral RCC accounted for 87.9% of bilateral cases (29/33).
- Partial nephrectomy was performed in 100% of patients.
- Actuarial 5-year overall survival was 84.5%, and disease-specific survival was 93.3%.
Conclusions:
- Non-familial bilateral RCC represents a distinct group with a favorable prognosis.
- Partial nephrectomy is a crucial surgical approach.
- Long-term surveillance is necessary due to potential asynchronous tumor development.