[Psoriasis therapy today]

Area of Science:

• Dermatology
• Genetics
• Immunology

Context:

• Psoriasis, historically confused with leprosy, is now recognized as a distinct inherited skin condition.
• Prevalence in northern countries is 1-2%, influenced by genetic predisposition and environmental triggers.
• Clinical presentation includes characteristic silvery scales on erythematous skin.

Purpose:

• To provide an overview of psoriasis, encompassing its history, prevalence, etiology, clinical presentation, and management strategies.
• To outline a tiered therapeutic approach for psoriasis, from topical treatments to systemic therapies and hospitalization.
• To emphasize the importance of considering both objective disease activity and subjective patient experience in treatment planning.

Summary:

• Psoriasis is an inherited skin disorder with a prevalence of 1-2% in northern regions, triggered by factors like infections and stress.
• Characterized by silvery scales on erythematous skin, its management requires expertise and consideration of disease severity and patient-reported outcomes.
• Therapeutic options range from emollients and topical treatments (steroids, vitamin D) to systemic therapies (UV therapy, retinoids, methotrexate, cyclosporine) and hospitalization for severe cases.

Impact:

• Highlights the complexity of psoriasis management, necessitating a comprehensive approach.
• Underscores the need for experienced dermatological care to address diverse patient needs.
• Provides a framework for understanding the progression of psoriasis treatments, from basic to advanced interventions.