[Central nervous system involvement in hepatitis C virus infection]
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Updated: Aug 28, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
P Cacoub1, A Sbaï, P Hausfater
1Service de Médecine Interne, CHU Pitié-Salpêtrière, Paris.
Abstract:
Few well-documented cases of central nervous system involvement in patients with hepatitis C virus infection have been reported. We describe three patients (two men and one woman) with cerebral involvement (ischemia and/or hemorrhage). Hepatitis C virus infection was confirmed in all patients by polymerase chain reaction detection of hepatitis C virus RNA. These three cases document the occurrence of central nervous system involvement in patients with hepatitis C virus infection and mixed cryoglobulinemia. Cerebral involvement may be the initial manifestation of hepatitis C virus infection.
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