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Germinal centre cell kinetics
1Department of Cellular Pathology, John Radcliffe Hospital, Headington, Oxford, U.K.
The germinal centre is a fundamental component of the humoral immune response, representing a unique microenvironment where antigen-activated B lymphocytes undergo clonal expansion, mutate their immunoglobulin, and are subject to a stringent selection process based on their antigen affinity. This review highlights recent advances in the understanding of the cell kinetic process of activation, proliferation, differentiation, and death of germinal centre cells, which are beginning to provide important insights into the regulation of this highly complex reaction. Their definition may have considerable pathological import given the involvement of the germinal centre in non-Hodgkin's lymphomas and recent evidence suggesting that abnormal germinal centre reactions may be involved in the pathogenesis of Hodgkin's disease and some autoimmune diseases.
The germinal centre is a fundamental component of the humoral immune response, representing a unique microenvironment where antigen-activated B lymphocytes undergo clonal expansion, mutate their immunoglobulin, and are subject to a stringent selection process based on their antigen affinity. This review highlights recent advances in the understanding of the cell kinetic process of activation, proliferation, differentiation, and death of germinal centre cells, which are beginning to provide important insights into the regulation of this highly complex reaction. Their definition may have considerable pathological import given the involvement of the germinal centre in non-Hodgkin's lymphomas and recent evidence suggesting that abnormal germinal centre reactions may be involved in the pathogenesis of Hodgkin's disease and some autoimmune diseases.