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Liquid ventilation
1Division of Pediatric Critical Care, Medical College of Wisconsin, Milwaukee, USA.
Clinics in Perinatology
|October 21, 1998
Summary
Perfluorocarbon liquid perflubron shows promise for treating respiratory failure. Liquid ventilation with perflubron improved gas exchange in animal models and showed potential in preliminary human trials for respiratory distress syndrome and acute respiratory distress syndrome.
Area of Science:
- Pulmonary Physiology
- Respiratory Medicine
- Biomedical Engineering
Background:
- The fluid-filled lung is a model for pulmonary physiology but not therapeutics.
- Perflubron, a perfluorocarbon, has unique physicochemical and biologic properties.
- Therapeutic applications of liquid ventilation are emerging.
Purpose of the Study:
- To evaluate the efficacy of perflubron in treating hypoxic respiratory failure.
- To assess the potential of perflubron liquid ventilation (PLV) in clinical settings.
Main Methods:
- Animal models of hypoxic respiratory failure were used to demonstrate perflubron's efficacy.
- Preliminary clinical studies were conducted in neonates with respiratory distress syndrome (RDS) and congenital diaphragmatic hernia (CDH).
- Studies also included children and adults with acute respiratory distress syndrome (ARDS).
Main Results:
- Perflubron demonstrated efficacy in improving gas exchange and compliance in animal models.
- Preliminary clinical studies in neonates and adults with respiratory conditions showed promising results.
- Further pivotal prospective, controlled studies are needed.
Conclusions:
- Perflubron shows significant potential as a therapeutic agent for respiratory failure.
- Liquid ventilation with perflubron is a promising approach for improving pulmonary function.
- Additional research is required to confirm its clinical effectiveness.