Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liquid ventilation

S E Day1, R G Gedeit

  • 1Division of Pediatric Critical Care, Medical College of Wisconsin, Milwaukee, USA.

Clinics in Perinatology
|October 21, 1998
PubMed
Summary
This summary is machine-generated.

Perfluorocarbon liquid perflubron shows promise for treating respiratory failure. Liquid ventilation with perflubron improved gas exchange in animal models and showed potential in preliminary human trials for respiratory distress syndrome and acute respiratory distress syndrome.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liquid crystal alignment induced by micron-scale patterned surfaces.

Physical review. E, Statistical, nonlinear, and soft matter physics·2014
Same author

A prospective social and molecular investigation of gonococcal transmission.

Lancet (London, England)·2000
Same author

Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn.

Critical care medicine·1997
Same author

Tumor necrosis factor-induced E-selectin expression on vascular endothelial cells.

Critical care medicine·1996
Same author

Control and variability of gastric pH in critically ill children.

Critical care medicine·1993
Same author

Measles severity and serum retinol (vitamin A) concentration among children in the United States.

Pediatrics·1993
Same journal

Breathing Physiology into the Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

The Science and Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

Ex Utero Artificial Womb Support: Promising Future for Extremely Preterm Infants.

Clinics in perinatology·2026
Same journal

Advances in the Use of Cell-Based Therapies for Prevention of Bronchopulmonary Dysplasia.

Clinics in perinatology·2026
Same journal

Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant.

Clinics in perinatology·2026
Same journal

Modern Surfactant Delivery Methods with a Focus on Implementation of Surfactant Administration Through Laryngeal and Supraglottic Airways.

Clinics in perinatology·2026
See all related articles

Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine
  • Biomedical Engineering

Background:

  • The fluid-filled lung is a model for pulmonary physiology but not therapeutics.
  • Perflubron, a perfluorocarbon, has unique physicochemical and biologic properties.
  • Therapeutic applications of liquid ventilation are emerging.

Purpose of the Study:

  • To evaluate the efficacy of perflubron in treating hypoxic respiratory failure.
  • To assess the potential of perflubron liquid ventilation (PLV) in clinical settings.

Main Methods:

  • Animal models of hypoxic respiratory failure were used to demonstrate perflubron's efficacy.
  • Preliminary clinical studies were conducted in neonates with respiratory distress syndrome (RDS) and congenital diaphragmatic hernia (CDH).

Related Experiment Videos

  • Studies also included children and adults with acute respiratory distress syndrome (ARDS).

    • Main Results:

    • Perflubron demonstrated efficacy in improving gas exchange and compliance in animal models.
    • Preliminary clinical studies in neonates and adults with respiratory conditions showed promising results.
    • Further pivotal prospective, controlled studies are needed.

    Conclusions:

    • Perflubron shows significant potential as a therapeutic agent for respiratory failure.
    • Liquid ventilation with perflubron is a promising approach for improving pulmonary function.
    • Additional research is required to confirm its clinical effectiveness.