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Updated: Jul 31, 2026
10:24
Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
Published on: October 28, 2014
[Hypercalciuria]
1Service de physiologie, Hôpital Broussais, Paris.
La Revue Du Praticien
|October 22, 1998
Summary
Hypercalciuria, characterized by excessive daily calcium excretion, often stems from abnormal intestinal and renal handling of calcium. Treatment involves dietary changes and thiazide diuretics.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Disorders
Background:
- Hypercalciuria is a common disorder defined by daily calcium excretion exceeding 0.1 mmol/kg.
- It signifies increased calcium in extracellular fluid, originating from the intestine or bone.
- While sometimes secondary to conditions like hyperparathyroidism or cancer, it's frequently idiopathic.
Purpose of the Study:
- To define hypercalciuria and its underlying mechanisms.
- To differentiate between secondary and primary (idiopathic) causes.
- To outline the therapeutic approach for idiopathic hypercalciuria.
Main Methods:
- Clinical definition based on urinary calcium excretion thresholds.
- Differential diagnosis to identify secondary causes.
- Assessment of intestinal and renal tubular calcium handling.
Main Results:
- Hypercalciuria indicates elevated intestinal or bone calcium input.
- Idiopathic hypercalciuria involves abnormal epithelial calcium transport.
- Secondary causes require specific etiological treatment.
Conclusions:
- Hypercalciuria is a frequent disorder with diverse origins.
- Idiopathic hypercalciuria is characterized by abnormal calcium handling.
- Management includes dietary modifications and thiazide diuretics.
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