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[Apoptosis: the pharmacological aspects]
D B Uteshev1, A V Sergeev, B S Uteshev
1Department of Pharmacology, Russian State Medical University, Moscow, Russia.
Abstract:
The article deals with the latest achievements in the interpretation of the mechanism of programmed cell death (apoptosis). The effect of drugs on the different stages of the apoptotic signal conduction is analysed. The earliest prospects of creating apoptosis regulating agents are planned. It is suggested that tests for apoptosis should be included in the list of obligatory ones in the preclinical studies of new biologically active compounds.
Insights
This study explores programmed cell death (apoptosis) mechanisms and drug effects on its pathways. It proposes developing apoptosis-regulating drugs and mandatory apoptosis testing for new compounds in preclinical studies.
Area of Science:
- Molecular Biology
- Cell Biology
- Pharmacology
Context:
- Programmed cell death, or apoptosis, is a fundamental biological process.
- Understanding apoptosis mechanisms is crucial for developing new therapies.
- Current research focuses on the intricate signaling pathways involved in apoptosis.
Purpose:
- To review recent advancements in understanding the mechanism of programmed cell death (apoptosis).
- To analyze the impact of various drugs on different stages of apoptotic signal conduction.
- To outline future prospects for developing agents that regulate apoptosis.
Summary:
- The article details the latest findings on apoptosis mechanisms.
- It examines how drugs influence the various stages of apoptotic signal transmission.
- The study highlights the potential for creating novel apoptosis-regulating drugs.
Impact:
- Suggests incorporating apoptosis tests into mandatory preclinical evaluations for new biologically active compounds.
- Highlights the potential therapeutic applications of modulating apoptosis.
- Provides insights for drug discovery and development in cancer and other diseases.