Related Experiment Video
Updated: Aug 5, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
The normal association between newly replicated DNA and the nuclear matrix is abolished in cells infected by herpes
1Laboratorio de Biología Molecular, Facultad de Medicina, UAEM, Toluca, México.
Abstract:
In cells infected by herpes simplex virus type 1 (HSV1), a series of nuclear changes can be observed in a temporal sequence. Such changes are related to important modifications in the higher-order structure of host cell chromatin, such as loss of DNA loop supercoiling and wholesale DNA loop disorganization. It is known that the topological relationship between DNA and the nuclear substructure is a critical factor for proper nuclear physiology. Here we report that the usual association between newly replicated DNA and the nuclear substructure, commonly known as nuclear matrix, is abrogated in cells infected by HSV1, thus establishing a correlation between the virus-induced modifications in chromatin higher-order structure and a major biochemical change within the infected cell nucleus.
More Related Videos
Related Concept Videos
Retrovirus Life Cycles
Viral Recombination
Size and Structure of Viral Genomes
Herpes
Cytomegalovirus Disease
Genital Herpes

