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Clofibrate microcapsules: preparation and release rat studies

P L Madan, D K Madan, J C Price

    Journal of Pharmaceutical Sciences
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    This study explored clofibrate microencapsulation using gelatin. Clofibrate microcapsules exhibited predominantly zero-order release, with hardening time correlating to release rate.

    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Clofibrate is a lipid-regulating drug with potential for controlled release applications.
    • Microencapsulation offers a method to modify drug release profiles and improve stability.

    Purpose of the Study:

    • To investigate the microencapsulation of clofibrate using gelatin.
    • To characterize the dissolution behavior of the resulting clofibrate microcapsules.

    Main Methods:

    • Clofibrate was encapsulated in gelatin microcapsules via simple coacervation using sodium sulfate.
    • Microcapsules were hardened with formaldehyde for up to 8 hours.
    • Dissolution studies were performed to analyze drug release kinetics.

    Main Results:

    • Discrete, free-flowing clofibrate microcapsules were successfully prepared.

    Related Experiment Videos

  • Drug release did not follow square root of time or Langenbucher kinetics.
  • Predominantly zero-order release kinetics were observed for clofibrate from the microcapsules.
  • A linear relationship was established between microcapsule hardening times and the 50% drug release time (t50%).

    • Conclusions:

    • Gelatin microencapsulation provides a viable method for controlling clofibrate release.
    • Zero-order release kinetics were achieved, suggesting potential for sustained drug delivery.
    • Formaldehyde hardening time is a critical parameter influencing clofibrate release rate from microcapsules.