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[Drug-induced gingival hyperplasia]

F Nohl1, P Ferrari

  • 1Departement Innere Medizin, Inselspital, Bern.

Therapeutische Umschau. Revue Therapeutique
|October 28, 1998
PubMed
Summary
This summary is machine-generated.

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Kidney transplant patients on cyclosporin A and nifedipine can develop severe gingival hyperplasia. Discontinuing the calcium channel blocker significantly improved this side effect, reducing the need for dental surgery.

Area of Science:

  • Nephrology
  • Pharmacology
  • Oral Medicine

Background:

  • Solid-organ transplant recipients often require immunosuppressive therapy, with cyclosporin A being a common agent.
  • Cyclosporin A is associated with various side effects, including gingival hyperplasia.
  • Co-medication with other drugs can potentially alter the side effect profile.

Observation:

  • A case report details a kidney transplant recipient receiving both cyclosporin A and nifedipine.
  • This patient developed severe gingival hyperplasia.
  • Standard dental-surgical treatments offered only temporary relief.

Findings:

  • Discontinuation of nifedipine, a calcium channel blocker, led to significant improvement in gingival hyperplasia.
  • The hyperplasia resolved to a degree that no longer required specific dental intervention.

Related Experiment Videos

  • This suggests a potentiating effect of calcium channel blockers on cyclosporin-induced gingival hyperplasia.

    • Implications:

    • Calcium channel blockers may exacerbate cyclosporin A-induced gingival hyperplasia in transplant patients.
    • Management strategies should consider discontinuing or reducing doses of potentiating medications like calcium channel blockers.
    • This approach may decrease the need for invasive dental-surgical procedures in managing gingival overgrowth.