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Severe experimental uraemia does not decrease the population of rat pituitary somatotrophs

J Rodríguez¹, E Carbajo-Pérez, F Santos

¹Department of Paediatrics, University of Oviedo, Asturias, Spain.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|October 30, 1998

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Severe uremia in rats does not alter pituitary somatotroph number or size. These findings suggest that altered pituitary cell populations do not explain reduced growth hormone (GH) secretion in uremic rats.

Area of Science:

Endocrinology
Nephrology
Pituitary Gland Research

Background:

Severely uraemic rats exhibit depressed growth hormone (GH) secretion.
Changes in pituitary somatotroph populations may contribute to reduced GH secretion.

Purpose of the Study:

To investigate the population dynamics of pituitary somatotrophs in experimental uremic rats.
To determine if alterations in somatotroph number or size explain reduced GH secretion.

Main Methods:

Immunocytochemical detection and quantification of GH-producing cells in rat pituitary sections.
Comparison between 5/6 nephrectomized (uremic) and sham-operated (control) rats.

Main Results:

Nephrectomized rats showed severe uremia and growth retardation.

Related Experiment Videos

Increased overall pituitary cell density was observed in uremic rats.

No significant differences in GH cell density or cross-sectional area were found between groups.

Conclusions:

Severe experimental uremia impacts pituitary gland maturation.
Reduced GH secretion in uremia is not attributable to changes in somatotroph number or size.