In vitro characterization of poly(ethylene) glycol calcium citrate microspheres as a delivery system for the study of
A R Hunter1, E E Kirk, D H Robinson
1Department of Oral Rehabilitation, University of Otago, Dunedin, New Zealand.
Endodontics & Dental Traumatology
|October 31, 1998
Abstract:
The characterization of poly(ethylene) glycol calcium citrate microspheres is described. The calcium content and content uniformity of microspheres, prepared at five concentrations ranging from 46.56 micrograms/g to 81.49 mg/g, were determined by spectroscopy. Under sink conditions first-order in vitro dissolution kinetics were observed. Granules containing approximately 80 mg Ca++/g PEG gave an in vitro calcium release over a 3-day period similar to that of a calcium hydroxide product, Pulpdent.
