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Programmed cell death during Xenopus development: a spatio-temporal analysis

C Hensey1, J Gautier

  • 1Department of Genetics and Development and Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, New York, 10032, USA.

Developmental Biology
|November 10, 1998
PubMed
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Programmed cell death (PCD) occurs dynamically during early Xenopus development, particularly in the nervous system, tail, and sensory organs. This study details PCD patterns, revealing its crucial role in vertebrate embryonic development and morphogenesis.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Vertebrate Embryology

Background:

  • Programmed cell death (PCD) is vital for development, but its early vertebrate patterns remain unclear.
  • Understanding PCD is crucial for early embryonic tissue migration and pattern formation.

Purpose of the Study:

  • To map the spatio-temporal patterns of PCD in early Xenopus development (fertilization to tadpole stage).
  • To investigate the role of PCD in neurogenesis, tail, and sensory organ development.

Main Methods:

  • Whole-mount in situ DNA end-labeling (TUNEL protocol) on Xenopus embryos.
  • Serial sectioning of TUNEL-stained embryos for detailed analysis.

Main Results:

  • First cell death detected during gastrulation, exhibiting dynamic and reproducible patterns.

Related Experiment Videos

  • Significant PCD observed during neural induction, neural plate patterning, and neurogenesis.
  • High levels of cell death noted in developing tail and sensory organs.

    • Conclusions:

    • This is the first comprehensive description of PCD patterns in early vertebrate development.
    • PCD plays a significant role in Xenopus embryonic patterning and morphogenesis.
    • Findings provide a foundation for future research on PCD's developmental functions.