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[A serological study on the immunization schedule at first dose of domestic BRD II strain rubella vaccine]
Insights
This study recommends an 8-month-old immunization schedule for the BRD II rubella vaccine in China. The research evaluated antibody levels in children aged 6-18 months to determine optimal vaccination timing.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Context:
- Rubella vaccine immunization schedules are crucial for disease prevention.
- Understanding serological responses in infants is key to optimizing vaccine efficacy.
- Previous studies have not definitively established the optimal age for initial rubella vaccination.
Purpose:
- To determine the optimal age for the initial vaccination with the domestic BRD II strain rubella vaccine.
- To assess the serological response (hemagglutination inhibition antibody levels) in children vaccinated at different ages.
- To inform the national immunization program in China.
Summary:
- A serological study was conducted on 268 children aged 6-18 months in Yantai, China, to evaluate rubella vaccine response.
- Pre-vaccination antibody levels were low across all age groups, with high negative rates.
- Post-vaccination, antibody levels increased significantly in all groups, showing no significant difference based on prior titers, supporting an 8-month vaccination start.
Impact:
- Provides evidence-based recommendation for an updated rubella vaccine schedule in China.
- Contributes to the understanding of rubella vaccine immunogenicity in infants.
- Aims to improve rubella prevention strategies through optimized immunization timing.
Abstract:
In order to develop a valid immunization schedule on the initial vaccination at different age of domestic BRD II strain rubella vaccine, a total number of 268 children at the age of 6 to 18 months from Yantai city of Shandong Province, China were selected for the serological study on hemagglutination inhibition (HI) antibody level against rubella from August to October, 1995. The results showed that the negative rates of HI antibody among children of 6, 7, 8, 9, 12 and 18 month olds before inoculation with rubella vaccine were 100.00%, 95.56%, 93.02%, 96.36%, 97.96% and 93.94% with geometric mean titers (GMTs) 0.00, 1.17, 1.21, 1.12, 1.07 and 1.13, respectively. After one month of immunization with rubella vaccine, the positive rates and GMTs of HI antibody were 97.67%, 95.56% 97.67%, 98.18%, 97.96%, 96.67% and 110.17, 197.02, 155.32, 177.63, 192.92, 142.17, respectively. There was no significant difference on immuno-response to rubella vaccine in children regardless the previous titers. Taking these results together with the current vaccine immunization schedule for expanded programme on immunization (EPI) in China into consideration, the author recommended that the immunization schedule at first vaccination for BRD II strain rubella vaccine should be started at 8 month olds.