[A study on polycyclic aromatic hydrocarbon-DNA adduct in lung cancer patients exposed to indoor coal-burning smoke]
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Updated: Oct 27, 2026

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
Published on: May 29, 2019
1Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing.
Abstract:
The objective of this study is to explore the etiology and early risk evaluation of lung cancer in Xuanwei County, Yunnan Province of China. Polycyclic aromatic hydrocarbon (PAH)-DNA adduct in brushing cells from fibrobronchoscopy was determined in 30 cases with lung cancer in Xuanwei County and 10 controls in Kunming, Yunnan Province by 32P-postlabelling assay. Results showed that PAH-DNA levels in lung cancer patients of Xuanwei County were much more higher than those in controls. It suggested that air pollution caused by indoor coal-burning associated directly with the occurrence of lung cancer, and detection of DNA adduct could be used as an indicator for its risk assessment in population.
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