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[Historical vision of shock]

C Dosne Pasqualini1

  • 1Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires. chdosne@hotmail.com

Medicina
|November 17, 1998
PubMed
Summary

Early research linked stress and shock, suggesting adrenal insufficiency. Ascorbic acid and cortisone showed protective effects against hemorrhagic shock in guinea pigs, hinting at metabolic underpinnings.

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Area of Science:

  • Endocrinology
  • Physiology
  • Biochemistry

Context:

  • The study builds upon Hans Selye's foundational work on stress and the General Adaptation Syndrome, initiated in 1936.
  • The author's early research proposed adrenal insufficiency as a cause of shock, stemming from metabolic demands.

Purpose:

  • To investigate the role of glucose metabolism in hemorrhagic shock.
  • To explore potential therapeutic interventions for shock based on metabolic pathways.

Summary:

  • Hemorrhagic shock was induced in guinea pigs, resulting in 94% lethality.
  • Administration of ascorbic acid (200 mg) prevented death, while cortisone administration led to 40% survival.
  • Desoxycorticosterone showed no significant effect, suggesting a specific role for certain adrenal compounds or metabolic processes.

Impact:

  • Provides historical context for understanding shock mechanisms.
  • Highlights the potential of ascorbic acid and corticosteroids in managing hemorrhagic shock.
  • Suggests further research into the metabolic pathways underlying shock and adrenal function.

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