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Related Experiment Videos

Dystroglycan in development and disease

M Durbeej1, M D Henry, K P Campbell

  • 1Howard Hughes Medical Institute, Department of Physiology and Biophysics, Iowa City, IA 52242, USA. madeleine-durbeej@uiowa.edu

Current Opinion in Cell Biology
|November 18, 1998
PubMed
Summary
This summary is machine-generated.

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Dystroglycan, a key cell surface receptor, is crucial for development and disease. Recent research clarifies its structure, function, and role in muscular dystrophies and pathogen binding.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Developmental Biology

Background:

  • Dystroglycan is a cell surface receptor for laminin and agrin.
  • Its precise biological role has been under investigation.

Purpose of the Study:

  • To elucidate the biological role of dystroglycan in development and disease.
  • To understand the structure and function of dystroglycan.

Main Methods:

  • Structural studies of dystroglycan.
  • Analysis of dystroglycan binding partners.
  • Targeted gene disruption studies.

Main Results:

  • Dystroglycan's structure and function are now better understood.
  • Dystroglycan is critical in the pathogenesis of muscular dystrophies.

Related Experiment Videos

  • Dystroglycan acts as a receptor for a human pathogen.

    • Conclusions:

    • Dystroglycan plays a vital role in early development, organ morphogenesis, and synaptogenesis.
    • Dysfunctional dystroglycan is linked to muscular dystrophies.
    • Dystroglycan is a significant target for understanding disease and development.