Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Repression by the Mad(Mxi1)-Sin3 complex

N Schreiber-Agus1, R A DePinho

  • 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. agus@aecom.yu.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|November 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation.

Leukemia·2019
Same author

Challenges of Pre- and Post-Test Counseling for Orthodox Jewish Individuals in the Premarital Phase.

Journal of genetic counseling·2015
Same author

Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.

The Journal of steroid biochemistry and molecular biology·2015
Same author

Cognitive and Antipsychotic Medication Use in Monoallelic GBA-Related Parkinson Disease.

JIMD reports·2014
Same author

Transcranial sonography and functional imaging in glucocerebrosidase mutation Parkinson disease.

Parkinsonism & related disorders·2012
Same author

Somatic p16(INK4a) loss accelerates melanomagenesis.

Oncogene·2010
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

The Mad(Mxi1) family antagonizes Myc

Area of Science:

  • Molecular biology
  • Cancer research
  • Cellular signaling

Background:

  • Myc proteins are crucial for cell growth and transformation.
  • The Mad(Mxi1) family acts antagonistically to Myc.
  • Understanding this balance is key to cancer insights.

Purpose of the Study:

  • To review the literature on the Mad(Mxi1) family.
  • To explore the molecular mechanisms of Mad(Mxi1) in opposing Myc.
  • To highlight the role of Mad(Mxi1) as potential tumor suppressors.

Main Methods:

  • Literature review
  • Analysis of molecular mechanisms
  • Comparison of Myc and Mad(Mxi1) functions

Main Results:

Related Experiment Videos

  • Mad(Mxi1) proteins inhibit Myc's functions.
  • They compete with Myc for dimerization and DNA binding.
  • Mad(Mxi1) proteins recruit gene expression repressors.

Conclusions:

  • The Mad(Mxi1) family represents a new class of tumor suppressors.
  • Their antagonistic actions on Myc are critical in normal and neoplastic cells.
  • Further research into Mad(Mxi1) mechanisms can inform cancer therapies.