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Vascular gene therapy

J W Thomas1, M D Kuo, M Chawla

  • 1Division of Diagnostic Imaging, Vascular and Interventional Section, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|November 20, 1998
PubMed
Summary
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Radiologists play a key role in tracking gene therapy outcomes using medical imaging. Advanced vascular and interventional radiology techniques facilitate minimally invasive gene delivery and monitoring.

Area of Science:

  • Biomedical engineering
  • Medical imaging
  • Molecular medicine

Background:

  • Gene therapy represents a significant advancement in modern medicine.
  • Radiologists are essential for monitoring gene therapy efficacy through imaging techniques.
  • Vascular and interventional radiology offer minimally invasive methods for gene delivery.

Purpose of the Study:

  • To highlight the integral role of radiologists in gene therapy.
  • To discuss the application of vascular and interventional radiology in gene delivery.
  • To outline the mechanisms and delivery methods of gene therapy.

Main Methods:

  • Gene therapy involves gene augmentation or gene blocking (e.g., antisense oligonucleotides).
  • Viral and nonviral vectors are utilized for gene delivery.

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  • Delivery methods include ex vivo and in vivo approaches, such as catheter-based techniques.

    • Main Results:

    • The vascular wall is a prime target for gene therapy due to its accessibility and biological significance.
    • Various catheter systems are being developed for precise vector delivery.
    • Minimizing vector shedding and systemic effects is crucial for optimal outcomes.

    Conclusions:

    • Radiologists need to understand gene therapy principles and participate in clinical trials.
    • Vascular and interventional radiology techniques are well-suited for gene therapy delivery and monitoring.
    • Developing advanced catheter systems will improve the safety and efficacy of gene transfer.