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Updated: Sep 18, 2026

Preparation of Murine Submandibular Salivary Gland for Upright Intravital Microscopy
Published on: May 7, 2018
Lymphoid complement of the human salivary glands: function and pathology
E Ciccone1, M Truini, C E Grossi
1National Institute for Cancer Research, Genoa, Italy.
Abstract:
In normal human salivary glands the Duct-Associated Lymphoid Tissue (DALT) is poorly developed. In contrast, in the course of autoimmune disorders, typified by Sjögren's syndrome (SS), organized lymphoid accumulations are formed around the ducts. B cell-dependent zones with secondary follicles and T cell-dependent zones with HEV are detected in these lymphoid structures. In addition, the duct epithelium is infiltrated by abundant lymphocytes. A persistent antigenic stimulation may lead to development of B-cell Mucosa-Associated Lymphoid Tissue (MALT) lymphomas that, in low-grade cases, maintain the lobular organization of normal and of SS salivary glands.
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