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Desmoplastic fibroblastoma
J M Junkins-Hopkins1, W C Johnson
1Department of Dermatology, University of Pennsylvania, Philadelphia, USA.
Journal of Cutaneous Pathology
|November 24, 1998
Summary
A rare fibrous soft-tissue tumor presenting as a cutaneous and subcutaneous nodule was identified. Histologic analysis revealed characteristic fibroblasts, abundant mucin, and mast cells, aiding in diagnosis.
Area of Science:
- Dermatopathology
- Soft Tissue Oncology
- Surgical Pathology
Background:
- Distinctive fibrous soft-tissue tumors have been previously reported in subcutaneous and intramuscular locations.
- These tumors present a diagnostic challenge due to their unique histologic features.
Observation:
- A case of a 48-year-old woman with a 2-cm cutaneous and subcutaneous nodule on the left arm is presented.
- The nodule exhibited features consistent with previously described fibrous soft-tissue tumors.
Findings:
- Excisional biopsy revealed a well-circumscribed tumor replacing dermal and subcutaneous tissue.
- Histology showed hypocellularity with spindled fibroblasts dissecting collagen bundles, abundant mucin (Alcian blue positive), and mast cells.
- Immunohistochemistry demonstrated positivity for Vimentin and Factor XIIIa, with negativity for S-100, desmin, actin, and keratin.
Implications:
- This case expands the known clinical presentations of this rare fibrous tumor.
- Accurate histologic and immunohistochemical characterization is crucial for differentiating this entity from other soft-tissue neoplasms.
- Further research may elucidate the specific cell of origin and behavior of this tumor.