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Apolipoprotein E regulatory region genotype in schizophrenia
T Shinkai1, O Ohmori, H Kojima
1Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. shinkai@med.uoeh-u.ac.jp
Neuroscience Letters
|December 1, 1998
Summary
This study investigated the association between the ApoE gene
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Schizophrenia is often associated with cognitive impairment, suggesting potential neurodegenerative links.
- Apolipoprotein E (ApoE) is genetically linked to Alzheimer's disease and is a candidate gene for schizophrenia.
- Novel functional polymorphisms in the ApoE transcriptional regulatory region have been identified.
Purpose of the Study:
- To determine if specific ApoE gene polymorphisms (-491A/T and -219G/T) are associated with schizophrenia risk.
- To investigate the role of the ApoE regulatory region in schizophrenia susceptibility.
Main Methods:
- Genotyping of two ApoE polymorphisms (-491A/T and -219G/T) in 144 schizophrenia patients and 134 controls.
- Statistical analysis to assess the association between polymorphisms and schizophrenia.
Main Results:
- No significant positive associations were found between the studied ApoE polymorphisms and schizophrenia.
- The findings do not support a link between these specific ApoE regulatory region variants and schizophrenia risk.
Conclusions:
- The transcriptional regulatory region of the ApoE gene, specifically the -491A/T and -219G/T polymorphisms, does not appear to confer increased susceptibility to schizophrenia.
- These findings help to exclude specific ApoE gene regions as a major genetic factor in schizophrenia etiology.