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Stature of Russian children with isolated cleft lip and palate
J A Nackashi1, A L Rosenbloom, R Marks
1University of Florida Craniofacial Center, Gainesville 32610, USA.
Insights
Russian children with repaired cleft lip and palate (CLP) aged 4-10 years show no increased risk of short stature when compared to U.S. growth norms. Most children
Area of Science:
- Pediatric endocrinology
- Genetics
- Craniofacial anomalies
Background:
- Cleft lip and palate (CLP) is a common congenital condition affecting facial development.
- Growth patterns in children with CLP can be influenced by genetic and environmental factors.
- Limited data exists on the stature of Russian children with CLP.
Purpose of the Study:
- To evaluate the stature of Russian children aged 4-10 years with repaired cleft lip and palate (CLP).
- To determine if there is an increased risk of short stature in this population.
- To compare their growth against established U.S. norms.
Main Methods:
- A cohort of 112 Russian children with repaired unilateral CLP (ages 4-10) were assessed.
- Height measurements, physical examinations, and medical records were reviewed.
- U.S. National Center for Health Statistics (NCHS) growth data and parental heights were used for comparison.
Main Results:
- The majority of Russian children's heights fell within the -1 to +1 standard deviation (SD) range based on U.S. norms.
- Sixty-two percent of children were below the 50th percentile for age-matched American children.
- The distribution outside the -1 to +1 SD range was statistically comparable to general population expectations.
Conclusions:
- No increased risk of true short stature was identified in 4- to 10-year-old Russian children with repaired CLP.
- Growth appears comparable to U.S. standards, suggesting successful management or inherent growth potential.
- Further longitudinal studies could provide more insights into long-term growth trajectories.
Objective:
To evaluate the stature of Russian children with cleft lip and palate (CLP).
Design:
One hundred twelve Russian children predominantly with repaired unilateral CLP 4 through 10 years of age underwent studies including height measurement, physical examinations, and record review. Children with health concerns that could affect growth were excluded. U.S. growth data from the National Center for Health Statistics (NCHS) and Russian parental heights were used in the absence of Russian growth norms.
Results:
Based on U.S. norms, the distribution curve for heights for the Russian children was largely confined to the +1 to -1 standard deviation (SD) range. Sixty-two percent of the Russian children had heights below the 50th percentile for American female and male children of the same age. The proportion of children found outside the +1 to -1 SD range approximated the proportion expected statistically for the general population, with 14.4% < -1 SD (16th percentile) and 12% > +1 SD (84th percentile). A total of 3.6% of the children ranked below the third percentile, which is close to the expected 3%. Russian parents' (n = 209) mean heights were 0.5 SD below NCHS's 50th percentile values for adults.
Conclusion:
These results indicate that there is no increased risk of true short stature in 4- to 10-year-old Russian children with repaired CLP.