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Nonsteroidal anti-inflammatory drug enteropathy
1Gastroenterology Unit, Glasgow Royal Infirmary, Scotland.
Gastrointestinal Endoscopy Clinics of North America
|December 3, 1998
Summary
Non-steroidal anti-inflammatory drugs (NSAID) can cause significant small intestine damage, known as NSAID enteropathy. Enteroscopy aids in diagnosing and managing this condition, which can lead to serious complications.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs (NSAID) is well-known.
- NSAID-induced damage extending to the small intestine (enteropathy) is less recognized.
- NSAID enteropathy can cause obscure bleeding, perforation, and obstruction.
Purpose of the Study:
- To provide an update on NSAID enteropathy.
- To discuss clinical features, endoscopic appearance, pathology, and outcomes.
- To highlight the role of enteroscopy in managing NSAID enteropathy.
Main Methods:
- Literature review and synthesis of recent data.
- Analysis of enteroscopic findings (endoscopic and microscopic).
- Review of clinical management and patient outcomes.
Main Results:
- Clinically significant ulceration is found in the small intestine in NSAID enteropathy.
- Enteroscopy reveals characteristic endoscopic and microscopic features.
- Enteroscopy information is crucial for patient management.
Conclusions:
- NSAID enteropathy is a significant clinical entity beyond the upper GI tract.
- Enteroscopy is invaluable for diagnosing and managing NSAID enteropathy.
- Understanding NSAID enteropathy improves patient outcomes.