Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Database of protein sequence alignments: PIR-ALN

G Y Srinivasarao1, L S Yeh, C R Marzec

  • 1Protein Information Resource, National Biomedical Research Foundation, 3900 Reservoir Road N.W., Washington, DC 20007, USA. geetha@nbrf.georgetown.edu

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exposure control at the first dark-field chest radiography demonstrator system.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.

BMC musculoskeletal disorders·2025
Same author

Parity-dependent state transfer for direct entanglement generation.

Nature communications·2025
Same author

Assessment of the Factors Influencing the Recording Performance of Circumneural Electrodes.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Same author

Spectral photon counting for panoramic dental imaging.

Biomedical physics & engineering express·2023
Same author

Multi-Scale Investigation of Human Renal Tissue in Three Dimensions.

IEEE transactions on medical imaging·2022
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

The Protein Information Resource (PIR) provides curated protein sequence alignments, aiding in sequence classification and standardization. This database facilitates research by offering accessible, updated alignment data for protein families and superfamilies.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Computational Biology

Background:

  • The Protein Information Resource (PIR) has been a key resource for protein sequence data since 1991.
  • Curated protein sequence alignments are crucial for understanding protein function and evolution.
  • Standardization of protein nomenclature and features is essential for data sharing and interpretation.

Purpose of the Study:

  • To describe the Protein Information Resource (PIR) database of curated protein sequence alignments.
  • To highlight the utility of the PIR database in protein classification and standardization.
  • To provide information on accessing and querying the PIR alignment data.

Main Methods:

  • Generation of multiple sequence alignments using CLUSTAL V/W.

Related Experiment Videos

  • Interactive checking and correction of alignments using ALNED.
  • Utilizing the ATLAS information retrieval system for browsing and querying.

    • Main Results:

    • The PIR database contains superfamily, family, and homology domain alignments.
    • The database has facilitated sequence classification and the definition of new homology domains.
    • Standardized protein names, features, and keywords have been disseminated.

    Conclusions:

    • The PIR database serves as a valuable resource for protein sequence analysis and research.
    • The integration of alignment generation, editing, and retrieval tools enhances data usability.
    • Regular updates ensure the database remains current and relevant for the scientific community.