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Plasma viscosity in nephrotic Nigerians

E Oviasu1, A A Famodu, E A Ojeh

  • 1Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.

Clinical Hemorheology and Microcirculation
|December 16, 1998
PubMed
Summary
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Nephrotic Nigerian patients exhibit higher plasma viscosity and fibrinogen levels, potentially increasing cardiovascular risk. This study highlights key haemorheological changes in nephrotic disease.

Area of Science:

  • Nephrology
  • Haemorheology
  • Biochemistry

Background:

  • Plasma viscosity is a critical haemorheological parameter.
  • Nephrotic syndrome is associated with complex physiological changes.
  • Understanding these changes is vital for managing patient outcomes.

Purpose of the Study:

  • To determine plasma viscosity and its correlation with plasma fibrinogen and immunoglobulin levels in Nigerian nephrotic patients.
  • To compare these parameters between nephrotic patients and healthy controls.

Main Methods:

  • A simple and reproducible 'syringe viscometer' method was employed.
  • Plasma viscosity, plasma fibrinogen, and immunoglobulin (IgG, IgM, IgA) levels were measured.
  • Measurements were conducted on 27 Nigerian nephrotic patients and 30 healthy controls.

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Main Results:

  • Nephrotic patients showed significantly higher relative plasma viscosity (RPV), plasma fibrinogen (PFC), and IgM levels compared to controls (p < 0.001).
  • Conversely, IgG and IgA levels were significantly lower in nephrotic patients (p < 0.05 and p < 0.01, respectively).
  • Plasma fibrinogen and IgM levels positively correlated with RPV in nephrotic patients (r=0.444, p < 0.05 and r=0.452, p < 0.02, respectively).

Conclusions:

  • Elevated plasma viscosity in nephrotic patients is linked to increased plasma fibrinogen and IgM levels.
  • These haemorheological alterations may predispose nephrotic patients to a higher long-term risk of cardiovascular morbidity.
  • The findings underscore the importance of monitoring haemorheological parameters in nephrotic syndrome.