Changes in corneal epithelial barrier function after excimer laser photorefractive keratectomy

Area of Science:

• Ophthalmology
• Corneal Surgery
• Excimer Laser Procedures

Background:

• Excimer laser photorefractive keratectomy (PRK) is a common refractive surgery.
• Assessing corneal epithelial barrier function is crucial for post-operative recovery.
• Understanding healing timelines aids in managing patient expectations and care.

Purpose of the Study:

• To evaluate corneal epithelial barrier function following PRK using fluorophotometry.
• To quantify changes in corneal epithelial permeability after excimer laser surgery.
• To determine the time course of barrier function restoration.

Main Methods:

• Fluorophotometry was used to measure corneal epithelial permeability to sodium fluorescein.
• Measurements were taken at 1, 2, and 3 weeks after PRK in 25 eyes.
• Corneal epithelial healing time and corrected diopter were also analyzed.

Main Results:

• Corneal epithelial permeability significantly increased at 1 week post-PRK.
• Barrier function returned to preoperative levels by 2 weeks after surgery.
• No statistically significant differences were found based on healing day or corrected diopter.

Conclusions:

• PRK temporarily impairs corneal epithelial barrier function.
• Normal barrier function is typically restored within two weeks of PRK.
• Minimizing further epithelial trauma during the initial post-operative period is recommended.