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Related Experiment Videos

Cerebral ischemic events associated with prolapsing mitral valve

H J Barnett, M W Jones, D R Boughner

    Archives of Neurology
    |November 1, 1976
    PubMed
    Summary

    Prolapsing mitral valve may cause recurrent ischemic events like transient ischemic attacks (TIAs) and strokes in younger adults. These events are linked to emboli from the abnormal mitral valve, differing from arteriosclerosis-related causes.

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    Area of Science:

    • Cardiology
    • Neurology
    • Vascular Medicine

    Background:

    • Transient ischemic attacks (TIAs) and strokes are typically associated with arteriosclerosis, particularly in older individuals.
    • Understanding the etiology of TIAs and strokes in younger populations is crucial for effective diagnosis and treatment.

    Observation:

    • Twelve patients under 50 with recurrent TIAs and strokes were identified.
    • These patients lacked typical risk factors such as arteriosclerotic cerebral vascular disease, hypertension, and oral contraceptive use.
    • All patients presented with a prolapsing mitral valve, confirmed via angiocardiography.

    Findings:

    • The average age of patients with TIAs and prolapsing mitral valve was 38 years, significantly younger than the 62 years seen in arteriosclerosis-related TIA cases.

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  • A strong association was observed between prolapsing mitral valve and ischemic cerebrovascular events in this cohort.
  • The study proposes that emboli originating from the abnormal mitral valve, potentially with co-existing cardiac arrhythmias, are the cause of these events.

    • Implications:

    • Prolapsing mitral valve should be considered a potential cause of TIAs and strokes, especially in younger patients without traditional risk factors.
    • This finding may lead to revised diagnostic protocols for cryptogenic strokes and TIAs.
    • Further research into the embolic potential of prolapsing mitral valve and its management is warranted.