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Related Experiment Videos

Fosphenytoin in infants

M Takeoka1, K S Krishnamoorthy, T B Soman

  • 1Department of Neurology, Massachusetts General Hospital, Boston 02114, USA.

Journal of Child Neurology
|December 16, 1998
PubMed
Summary

Fosphenytoin, a safer alternative to phenytoin for treating seizures, presented challenges in achieving therapeutic serum levels in infants. Dosing adjustments were often insufficient to maintain target phenytoin concentrations in this pediatric population.

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Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology
  • Pharmacokinetics

Background:

  • Phenytoin has a high pH (11), increasing risks of cardiovascular and cutaneous side effects.
  • Fosphenytoin, a prodrug of phenytoin, offers a near-neutral pH (8.6), enhancing safety and administration options (IV/IM).
  • Fosphenytoin is converted 1:1 to phenytoin (mg PE:mg), simplifying dose calculations.