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[Diagnostic imaging techniques in psychiatry]

H E Hulshoff Pol1, R S Kahn

  • 1Academisch Ziekenhuis, afd. Psychiatrie, Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|December 29, 1998
PubMed
Summary
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Brain imaging reveals structural and functional abnormalities in psychiatric disorders like schizophrenia. Research now focuses on the location, nature, and origin of these brain changes.

Area of Science:

  • Neuroscience
  • Psychiatry

Context:

  • Psychiatric disorders such as schizophrenia exhibit morphological and functional brain abnormalities.
  • Research has identified altered volumes in ventricles, gray matter, basal nuclei, thalamus, and limbic structures.

Purpose:

  • To investigate the location, characteristics, and origins of brain abnormalities in psychiatric diseases.
  • To shift focus from the existence of abnormalities to their specific nature and etiology.

Summary:

  • Altered brain activity is observed in cortical and subcortical regions, notably the frontal cortex, during cognitive and pharmacological challenges.
  • Factors like disease progression, genetics, and environment influence these brain abnormalities.
  • Imaging techniques are increasingly used, though clinical application remains limited.

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Impact:

  • Advances understanding of the neurobiological underpinnings of psychiatric disorders.
  • Provides a foundation for future research into targeted treatments and diagnostic markers.
  • Highlights the complex interplay of genetic, environmental, and disease-related factors in brain pathology.