Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural interfaces for regenerated nerve stimulation and recording

P Dario1, P Garzella, M Toro

  • 1Scuola Superiore Sant' Anna, Pisa, Italy.

IEEE Transactions on Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
|December 29, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass.

IEEE open journal of engineering in medicine and biology·2024
Same author

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period.

APL bioengineering·2024
Same author

Cardiovascular response to closed-loop intraneural stimulation of the right vagus nerve: a proof-of-concept study.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Same author

Neural Stimulation Hardware for the Selective Intrafascicular Modulation of the Vagus Nerve.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2023
Same author

Decoding bladder state from pudendal intraneural signals in pigs.

APL bioengineering·2023
Same author

Toward the Development of User-Centered Neurointegrated Lower Limb Prostheses.

IEEE reviews in biomedical engineering·2023

Researchers developed implantable neural interfaces (NIs) that promote nerve regeneration and restore function in peripheral nerves. These devices enable recording, stimulation, and show promise for future prosthetic control.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Peripheral nerve injuries often result in functional deficits.
  • Current neural interfaces face challenges in long-term biocompatibility and efficacy.
  • Regenerative approaches offer a promising avenue for restoring nerve function.

Purpose of the Study:

  • To develop and evaluate novel regeneration-type neural interfaces (NIs) for peripheral nerve repair.
  • To assess the biocompatibility, nerve regeneration, and functional recovery facilitated by the NIs.
  • To investigate the potential of NIs for recording and stimulation of regenerated peripheral nerves.

Main Methods:

  • Fabrication of implantable NIs using microfabrication and polymer-based guidance channels.

Related Experiment Videos

  • Implantation of NIs between severed sciatic nerves in a rabbit model.
  • Morphological, histological, and electrophysiological assessments of nerve regeneration and function.

    • Main Results:

    • Successful regeneration of peripheral nerves through the NIs was confirmed by morphological and histological analysis.
    • Electrophysiological testing demonstrated recovery of nerve electrical functionality.
    • Stimulation via the NIs elicited visible leg/foot contractions, indicating motor function restoration.

    Conclusions:

    • The developed neural interfaces effectively support peripheral nerve regeneration and functional recovery.
    • These NIs show potential for long-term implantation and reliable nerve interfacing.
    • Further development aims to integrate these NIs into prosthetic devices for advanced neural control.