Nitric oxide: a primer for the practicing anesthetist

Nitric oxide (NO) is receiving interest because of its use in patients with acute respiratory distress syndrome. Because more studies are being conducted, researchers are discovering a vast array of physiological effects attributable to NO. NO has been implicated as having a role in the endogenous regulation of blood pressure; smooth, skeletal, and cardiac muscle relaxation; renal and immune system functioning; and selective pulmonary vasodilation. This article looks at the pharmacological and physiological effects of NO and its current use in the clinical setting.