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Imaging the Human Immunological Synapse
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[Normal antibodies and immunologic reactivity]

M I Levi, T S Selezneva, M M Livshits

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 1, 1976
    PubMed
    Summary

    Natural antibodies against plague bacteria were found in most mice, except for one strain. Antibody levels correlated with the number of antibody-producing cells, suggesting a link between natural immunity and immune response.

    Area of Science:

    • Immunology
    • Microbiology
    • Infectious Diseases

    Background:

    • Natural antibodies play a role in innate immunity against various pathogens.
    • The presence and levels of natural antibodies can vary significantly between different inbred mouse strains.
    • Understanding natural antibody responses is crucial for developing effective vaccines and treatments for infectious diseases like plague.

    Purpose of the Study:

    • To investigate the presence and levels of natural antibodies against the capsular antigen of the plague bacterium in different mouse strains.
    • To determine the correlation between natural antibody levels and the frequency of antibody-forming cells in non-immunized mice.
    • To establish a quantitative relationship between natural antibody levels and the cellular immune response.

    Main Methods:

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    • Sera from non-immunized mice of various strains were tested for antibodies to the plague capsular antigen.
    • Mice were administered the capsular antigen, and antibody-forming cells were quantified.
    • Statistical analysis was used to determine correlations between natural antibody levels, antibody-forming cells, and immunoglobulin concentrations.

    Main Results:

    • Antibodies to the plague capsular antigen were detected in 6 out of 7 mouse strains, with none found in the DBA/2 strain.
    • A quantitative correlation was observed between natural antibody levels and the number of antibody-forming cells after antigen administration.
    • A mathematical equation was derived to describe the association between natural antibody levels and antibody-forming cells in the spleen.
    • A satisfactory correlation was found between blood immunoglobulin concentration and splenic plasma cell counts.

    Conclusions:

    • Natural antibodies against the plague bacterium are present in most mouse strains and their levels correlate with the capacity to form specific antibodies upon antigen exposure.
    • The study provides a quantitative model for the relationship between natural antibody levels and the cellular immune response in mice.
    • These findings contribute to understanding the innate immune mechanisms underlying plague resistance and inform vaccine development strategies.