[Changes in the concept of multiple sclerosis]

Area of Science:

• Neuroimmunology
• Neurology
• Medical Imaging

Context:

• Multiple Sclerosis (MS) is an incurable neuroinflammatory disease.
• Understanding of MS pathogenesis has evolved significantly.
• Advances in diagnostic and therapeutic strategies are crucial.

Purpose:

• To summarize recent (10-year) advancements in Multiple Sclerosis.
• To highlight new insights into inflammatory processes and disease dynamics.
• To discuss the impact of novel therapeutic agents.

Summary:

• Sophisticated immunological methods have elucidated the inflammatory processes in the central nervous system in MS.
• Advanced Magnetic Resonance (MR) imaging techniques allow for dynamic assessment of disease progression and histological changes.
• Clinical trials of new drugs demonstrate efficacy in managing MS, aiding classification and monitoring.

Impact:

• New drugs provide hope for patients and valuable tools for clinicians.
• Therapies can slow disease progression, mitigate tissue damage, and enhance quality of life.
• These advancements represent significant progress towards better MS management pending further curative therapies.