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High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes
T Berg1, A M Vandersteen, K D Janda
1Scripps Research Institute, Department of Chemistry, La Jolla, CA, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A 'combinatorial catalysis' strategy was utilized to both rapidly synthesized organometallic complexes and to screen them for catalytic activity in chemical reactions. The application of this strategy has yielded several metal-complexes that catalyze the hydrolysis of carboxylic acid esters efficiently.