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Hydroindenic-guanylhydrazones. Synthesis and evaluation as inotropic agents
C P Melero1, L G Sevillano, E Caballero
1Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The synthesis and inotropic activity of two families of hydroindenic compounds are described. Among them, a bis-guanylhydrazone derivative has demonstrated to produce an interesting positive inotropic effect on guinea pig atria, displaying at higher dosis a similar effect to that elicited by digoxin.