Related Experiment Videos
Conformational interconversions in peptide beta-turns: analysis of turns in proteins and computational estimates of
K Gunasekaran1, L Gomathi, C Ramakrishnan
1Molecular Biophysics Unit and Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India.
Journal of Molecular Biology
|January 8, 1999
Abstract:
The two most important beta-turn features in peptides and proteins are the type I and type II turns, which differ mainly in the orientation of the central peptide unit. Facile conformational interconversion is possible, in principle, by a flip of the central peptide unit. Homologous crystal structures afford an opportunity to structurally characterize both possible conformational states, thus allowing identification of sites that are potentially stereochemically mobile. A representative data set of 250 high-resolution (