Macromolecular exchanges between the nucleus and cytoplasm

The control of transcription and translation is of fundamental importance in cell biology. In this regard, the nuclear envelope is in a unique position to contribute to the regulation of these events, by directing macromolecular exchanges between the nucleus and cytoplasm. Such exchanges occur through the nuclear pore complexes, mainly by signal-mediated processes. Different signals are required for import and export. Specific cytoplasmic or nuclear receptors initially bind the signal-containing substrate, and the complex subsequently interacts with the pores. Additional factors then assist in translocation across the envelope. Current research is focused mainly on further characterization of transport receptors, translocation factors, as well as components of the nuclear pore complex, i.e., the nucleoporins. The ultimate goal is to understand the molecular interactions that occur among the different components of the transport apparatus, the energy sources for transport, and how variations in transport capacity are generated.