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[TSH-response to TRH in active coeliac disease in infants (author's transl)]
Annales D'Endocrinologie
|January 1, 1978
Insights
Infants with active gluten-induced enteropathy showed an exaggerated thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH). This condition was also linked to decreased levels of thyroid hormones T4 and T3.
Area of Science:
- Pediatric Endocrinology
- Gastroenterology
- Thyroid Research
Context:
- Active gluten-induced enteropathy affects infants.
- Thyroid function can be impacted by gastrointestinal disorders.
Purpose:
- To investigate thyroid function in infants with active gluten-induced enteropathy.
- To compare thyroid hormone levels and TSH response to TRH in affected infants versus controls.
Summary:
- Infants (3-19 months) with active gluten-induced enteropathy exhibited a heightened and prolonged plasma TSH response to TRH compared to controls.
- These patients also presented with statistically significant reductions in total and free thyroxine (T4) and triiodothyronine (T3) concentrations.
Impact:
- Highlights a potential link between celiac disease and thyroid dysfunction in infants.
- Suggests the need for monitoring thyroid health in pediatric patients with gluten-induced enteropathy.
- Provides data for understanding the systemic effects of gluten sensitivity beyond the gut.
Abstract:
In 11 infants of 3-19 months of age with active gluten-induced enteropathy, an exaggerated and sustained response of plasma TSH to TRH was observed as compared to controls. In these same patients, there was a decrease in total and free T4 and T3 concentrations. All these values were statistically different from controls.