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Immunotherapy of allergy: anergy, deletion, and immune deviation
1Department of Pathology and Immunology Monash University Medical School Commercial Road Prahran Victoria 3181 Australia. Jennifer. Rolland@med.monash.edu.au
Current Opinion in Immunology
|January 23, 1999
Abstract:
Decreased allergen-specific T cell proliferation and dysregulated cytokine synthesis accompany allergen immunotherapy, consistent with mechanisms of anergy and immune deviation. Recent studies emphasise the pivotal role of decreased T cell IL-4:IFN-gamma ratios. A landmark clinical trial of T cell epitope peptides for venom-immunotherapy shows efficacy and safety; murine models suggest intramolecular epitope-suppression inhibits responses to the whole allergen.