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Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein oxidation
S P Goss1, B Kalyanaraman, N Hogg
1Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226-0509, USA.
Methods in Enzymology
|January 27, 1999
Abstract:
Nitric oxide, when slowly released from a donor compound, has a potent inhibitory effect on the oxidative modification of LDL. This can be studied by monitoring changes in the lipid, protein, and antioxidant components of the LDL particle. In addition, the kinetics of LDL oxidation provides an insight into the mechanistic basis of the nitric oxide-dependent inhibition of LDL oxidation.